SIBBM 2024 • Frontiers in Molecular Biology

SIBBM 2024 • Frontiers in Molecular Biology

The time of Molecular Biology:
development, homeostasis and aging

The time of Molecular Biology:
development, homeostasis and aging

Trento, Italy • 17-19 June 2024

Trento, Italy • 17-19 June 2024

SIBBM 2024 • Frontiers in Molecular Biology

The time of Molecular Biology:
development, homeostasis and aging

Trento, Italy • 17-19 June 2024

Preliminary Programme


  • 12:20-13:30 Light lunch and registration
    13:30-13:40 Welcome address
    Francesca Demichelis, Prorettrice alla Ricerca, University of Trento
    Session I - RNA, from basic science to advanced therapies
    CHAIRS: Angela Gallo (Ospedale Pediatrico Bambino Gesù, Rome) and Francesco Nicassio (IIT, Milan)
    13:40-14:10 Danny Incarnato (University of Groningen, The Netherlands)
    Mapping the RNA structurome: from population average to ensemble deconvolution
    14:10-14:40 Dafne Campigli Di Giammartino (Center for Human Technologies IIT, Genoa, Italy)
    3D chromatin hubs support oncogenic programs in glioblastoma
    14:40-15:00 Nunzio Del Gaudio (University of Campania "L. Vanvitelli", Italy)
    Targeting m6A-epitrascriptome in leukemia
    15:00-15:20 Lucia Coscujuela Tarrero (Center for Genomic Science of IIT@SEMM, Milan, Italy)
    The role of RNA modifications in breast cancer spliceosomal vulnerability
    15:20-15:40 Petronilla Frugis (University of Bari, Italy)
    Harnessing endogenous ADARs for correcting a pathogenic G>A point mutation in SBF1
    15:40-16:00 Nicola Mosca (University of Campania "L. Vanvitelli", Italy)
    Small non-coding RNA’s journey to the mitochondria
    16:00-17:30 Poster Session A and coffee break
    17:30-18:30 Symposium: Science and Society
    Scienza e Politica: L'influenza delle conoscenze scientifiche nelle decisioni politiche

    Paolo Vineis (Imperial College, London, UK)
    Valeria Poli (University of Turin, Italy)
    Lucia Busatta (University of Trento, Italy)
    Giulia Casonato (Assessora a Transizione verde, Innovazione digitale e Partecipazione, Comune di Trento)

    18:45 Bus from Trento to Toblino
    19:15 Social dinner in Toblino Castle
  • Session II - Epigenetic modifications in health and disease
    CHAIRS: Tiziana Bonaldi (University of Milan) and Ian Marc Bonapace (University of Insubria, Varese)
    8:30-9:00 Maxim Greenberg (Institut Jacques Monod, Paris, France)
    Non-canonical functions of DNA methylation in mammals
    9:00-9:20 Livia Condemi (Centre for Genomic Regulation (CRG), Barcelona, Spain)
    Role of Polycomb Like Protiens during mESCs differentiation
    9:20-9:40 Marzia Munafò (European Molecular Biology Laboratory, Monterotondo, RM, Italy)
    Systematic and rapid maternal perturbations reveal the functional role of chromatin marks in oogenesis and inheritance
    9:40-10:00 Camilla Vitali (University of Milan, Italy)
    Genome-scale dependency maps reveal hints about the function and therapeutic value of an oncogenic transcription factor in human cancer
    10:00-10:20 Chiara Carrino (University of Rome “Tor Vergata”, Italy)
    Integrating transcriptomic and phosphoproteomic data to discover dysregulated transcriptional networks in lung cancer
    10:20-10:30 Tea Kacman (IMMAGINA Biotechnology)
    Unlock the power of tRNA with Nano-tRNAseq
    10:30-12:00 Poster Session B and coffee break
    12:00-12:30 Ernesto Guccione (Mount Sinai, New York, NY, USA)
    Oncofetal reprogramming fuels phenotypic plasticity in WNT-driven colorectal cancer
    12:30-13:00 Luca Magnani (The Institute of Cancer Research, London, United Kingdom)
    Sleepwalking through evolution: a tale of dormancy and hormone dependent breast cancer
    13:00-14:00 Lunch
    Session III - Aging and senescence
    CHAIRS: Caterina Missero (CEINGE, University of Naples) and Cosima T. Baldari (University of Siena)
    14:00-14:10 Introduction to the EMBL Lecture
    Cornelius Gross (European Molecular Biology Laboratory - EMBL, Monterotondo, Rome, Italy)
    14:10-14:40 EMBL Lecture
    Paolo Vineis (Imperial College, London, UK)
    Ageing: a molecular epidemiology perspective
    14:40-15:00 Simona Pepe (University of Bologna, Italy)
    Cell-cycle phase specific roles of alternative DNA polymerases and R-loops in genome instability by G-quadruplex structures
    15:00-15:20 Stefania Del Prete (European Molecular Biology Laboratory (EMBL), Heidelberg, Germany)
    Sex-bias immune aging and its interplay with X-inactivation escape genes at single-cell level
    15:20-15:40 Mario Chiariello (Istituto di Fisiologia Clinica, CNR, Siena, Italy)
    MAPK15 regulates NRF2 activity, oxidative stress and cellular senescence in normal and transformed lung cells
    15:40-16:00 Fabrizio Antonangeli (Institute of Molecular Biology and Pathology, CNR, Rome, Italy)
    Neutrophil-activating secretome characterizes palbociclib-induced senescence of breast cancer cells
    16:00-16:10 Giuseppe Martone (NEGEDIA)
    Multi-modal approaches in molecular biology
    16:10-17:40 Poster Session C and coffee break
    17:40-18:10 Francesco Neri (Fritz Lipmann Institute, Jena, Germany and University of Turin, Italy)
    Inflammaging and intestinal aging
    18:10-18:40 Valerio Orlando (King Abdullah University of Science and Technology, Saudi Arabia)
    The Ying Yang of retrotransposons activity in the soma: from junk to RNA tools for antiaging and tissue regeneration
    18:45-19:45 SIBBM members’ general assembly
  • Session IV - Stem cells and organoids for development and disease
    (Joint Session with Associazione di Biologia Cellulare e del Differenziamento - ABCD)
    CHAIRS: Massimo Gulisano (University of Catania and SCRB, Harvard University, Cambridge, MA, USA) and Alessandro Fiorenzano (CNR Institute of Genetics and Biophysics, Naples)
    8:30-8:50 Rossella Di Giaimo (Max Planck Institute of Psychiatry, Munich, Germany, University of Naples Federico II, Ludwig-Maximilians-University, Munich, Germany)
    Deciphering pathological mechanisms in a neurodevelopmental disease model: insights from extracellular vesicles
    8:50-9:10 Desirèe Valente (University Magna Graecia, Catanzaro, Italy)
    iPSCs-derived mosaic midbrain organoids (mMOs) reproduce neuropathological-relevant features of progressive supranuclear palsy (PSP)
    9:10-9:30 Martina Bertocchi (University of Milan, Italy)
    2D and 3D iPSC-derived neuronal models for the study of the role of lncRNA PHOX2B-AS1 in the pathogenesis of Congenital Central Hypoventilation Syndrome
    9:30-9:50 Stefano Biressi (University of Trento, Italy)
    A mesenchymal signature identifies distinct fractions of muscle stem cells with different modalities of activation and quiescence maintenance
    9:50-10:00 Emma Di Capua (AHSI Biotechnology)
    Measure what’s Important to your Cell: Agilent Seahorse XF Analysis opens up live-cell kinetic windows into cell function
    10:00-10:40 Coffee break
    10:40-11:10 Irene Faravelli (Harvard University, Cambridge, MA, USA)
    Brain Cortical Chimeroids to explore human development and disease
    11:10-11:40 Graziano Martello (University of Padua, Italy)
    Dissecting early human embryonic development with a 3D in vitro epiblast model
    11:40-11:50 Introduction to the Riccardo Cortese Lecture
    11:50-12:20 Riccardo Cortese Lecture
    Gabriella Minchiotti (CNR Institute of Genetics and Biophysics, Naples, Italy)
    Stem cell-based embryo models: challenges and opportunities for fundamental research and translation
    12:20-13:00 Prizes and wrap-up
  • The poster's maximum size is A0 (841 x 1189 mm; width x height).

    Correct format... poster should be PORTRAIT  poster should NOT be LANDSCAPE Wrong format...

    Poster presenters are required to be available for discussion during their assigned session. The distribution of posters in the three sessions is indicated below.

    For Poster Session A, posters can be put up from 12:30 to 16:00 on Monday, 17 June, and must be taken down from 17:30 to 19:00 on Monday, 17 June.

    For Poster Session B, posters can be put up from 8:00 to 10:30 on Tuesday, 18 June, and must be taken down from 12:00 to 13:30 on Tuesday, 18 June.

    For Poster Session C, posters can be put up from 13:30 to 16:10 on Tuesday, 18 June, and must be taken down from 17:40 to 20:00 on Tuesday, 18 June.

    Posters left behind will be removed and discarded by the venue personnel.

    Poster Session A: Monday, 17 June, 16:00-17:30.
    Poster Session B: Tuesday, 18 June, 10:30-12:00.
    Poster Session C: Tuesday, 18 June, 16:10-17:40.

    • Monday, 17 June, 16:00-17:30

      A.1 Natalia Abate, Naples
      Looking for CSTB partners during cortical development to understand EPM1 pathological phenotypes

      A.2 Sonia Amato, Padua
      Exploring striatal brain organoids: a model for studying Parkinson's and Huntington's diseases

      A.3 Sara Baldinelli, Povo (TN)
      Computational analysis of RNA expression among survival groups in amyotrophic lateral sclerosis

      A.4 Matteo Bertoli, Brescia
      ADAR therapeutic to tackle neurodegenerative disorders

      A.5 Michele Bissoli, Verona
      The absence of the human thioesterase ACOT8 negatively affects HIV-1 infectivity in vitro

      A.6 Davide Bressan, Trento
      mSWI/SNF mutations affect liver-specific regenerative response and reshape tissue microenvironment

      A.7 Maria Bruno, Verona
      Identifying splicing factors consensus sequences in Tau exon 6 through minigene tool

      A.8 Michele Carminati, Milan
      Investigating the role of H3K27me3 in epithelial ovarian cancer chemoresponse and mechanisms of resistance

      A.9 Elena Cerri, Povo (TN)
      Assessment of m6A-readers YTHDF2 inhibitors as Acute Myeloid Leukaemia therapeutics

      A.10 Marianna Ciuffreda, Trento
      Single-cell analysis to identify transcriptional heterogeneity in adolescent and pediatric myelodysplastic syndrome (PMDS)

      A.11 Giuseppina Covello, Padua
      Isoform-specific siRNAs as a potential therapeutic approach for tau-dependent neurodegenerative diseases

      A.12 Alberto Danielli, Bologna
      The ferric uptake regulator Fur mediates distal iron-dependent chromatin interactions and DNA looping in Helicobacter pylori

      A.13 Valeria Famà, Milan
      Nanodynamo quantifies the dynamics of RNA metabolism and reveals extensive coupling between steps of the RNA life cycle 

      A.15 Angelisa Frasca, Segrate (MI)
      Neural precursor cells rescue symptoms of Rett syndrome by activation of the Interferon γ pathway

      A.16 Silvia Gasparini, Rome
      Exploring the expression and functional role of circRmst in neuronal differentiation

      A.17 Gloria Griffante, Turin
      Transcriptome and microbiome analysis of Vulvodynia patients

      A.18 Charlotte Kilstrup-Nielsen, Busto Arsizio
      CDKL5 interacts with inhibitory postsynaptic proteins and regulates synaptic GABAA-receptor levels

      A.19 Andrea Lobascio, Turin
      Unraveling the contribution of cancer-associated fibroblasts to drug resistance in breast cancer

      A.20 Jessica Marinello, Bologna
      Transcription/replication conflicts occur at 5'-ends of highly-transcribed genes in early replicating zones and are attenuated by transcription factor IIS

      A.21 Valeria Mazzone, Naples
      Terpenes could function as senolytics, selectively eliminating human senescent mesenchymal stromal cells through programmed cell death induction

      A.22 Marina Mione, Trento
      The telomeric transcript TERRA is sensed by the RLR pathway and mediates  inflammation in models of cancer and aging

      A.23 Michela Nigro, Bologna
      Molecular engineering of a spheroid-penetrating phage nanovector for targeted photodynamic treatment of EGFR-expressing cancer cells

      A.24 Francesca Orso, Novara
      miR-214-driven cell metabolism rewiring leads to melanoma progression

      A.25 Lucia Pappagallo, Bologna
      Neurophage: development of a molecular engineered phage-based nanoplatform for non-invasive neuronal photostimulation

      A.26 Mariaceleste Pezzullo, Caserta
      A novel competing endogenous RNA network involving the lncRNA JPX, miR-378a-3p and its mRNA targets in lung adenocarcinoma

      A.27 Michele Sallese, Chieti
      Omics approaches to shed light on the pathogenetic mechanisms of Marinesco-Sjogren's syndrome and proposal of an innovative therapeutic strategy

      A.28 Rayan Slatni, Trento
      Alterations of gene expression profiles in mental diseases

      A.29 Daniela Taverna, Turin
      axl-miR-214sponge chimeric aptamers as therapeutic tools to target BRAF inhibitor resistant melanomas

      A.30 Elvia Valentini, Rome
      Unraveling the complex role of MEOX2 in the pathogenesis and therapeutic resistance of glioblastoma stem-like cells

      A.31 Daniele Viavattene, Turin
      mTOR triggers STAT3 S-P at the ER inhibiting calcium-mediated apoptosis

      A.32 Hasan Yilmaz, Pergine
      Deciphering translation machinery: long-read tRNA sequencing coupled with RiboLace

    • Tuesday, 18 June, 10:30-12:00

      B.1 Nicola Alessio, Naples
      IGFBP5: a key player in cellular senescence and aging processes

      B.2 Domenico Aprile, Naples
      Mitigation of senescence post-irradiation: senolytics and MUSE cells promote healthy aging in mice

      B.3 Giorgia Lucia Benedetto, Catanzaro
      Generation of patient-specific induced pluripotent stem cell-derived dopaminergic neurons as an in vitro model for proteinopathies

      B.4 Nicole Bettin, Brussels, Belgium
      Unravelling the mechanisms of mtDNA-dependent regulation of telomere length and investigating their therapeutical potential

      B.5 Guglielmo Bove, Naples
      Chronic myeloid leukemia cells depend on VIRMA for their proliferation

      B.6 Emma Busarello, Trento
      Interpreting single-cell messages in normal and aberrant hematopoiesis with the Cell Marker Accordion

      B.7 Nagaja Capitani, Siena
      A mutation in the ciliary protein Uncoordinated 119 disrupts immune synapse assembly in T lymphocytes

      B.8 Serena Carra, Modena
      SUMO2/3 conjugation of TDP-43 protects against aggregation

      B.9 Yari Ciani, Trento
      EV total RNA offers a dual perspective on prostate cancer patients’ prognosis through tumor and immune system cell profiles

      B.10 Andrea Corsi, Verona
      Regulation of Tau exons alternative splicing by RNA-binding proteins PTBP1 and RBM20

      B.11 Erica Lucia Crapanzano, Pisa
      Multiple CRISPR/Cas-based approaches in zebrafish to unravel the molecular mechanisms of Sotos Syndrome

      B.12 Moises Di Sante, Pavia
      Tracking structure, function, and cell cycle progression in development and morphogenesis with a genetically engineered hiPSC line (TEMPO)

      B.13 Luigi Fattore, Rome
      Tackling the invasive properties of drug resistant melanomas using locked nucleic acid (LNA) to inhibit the oncomiRs miR-4443 and miR-4488

      B.14 Teresa Maria Formica, Pavia
      A nanoparticle-based approach for allele-specific silencing of mutant Ryanodine Receptor gene (RyR2) in CPVT

      B.15 Mattia Furlan, Milan
      Decoding the human epitranscriptome across the RNA life cycle through Nanopore sequencing

      B.16 Rachele Ghirardo, Padua
      Assessing gene therapy strategies for polyGlutamine diseases

      B.17 Meriem Hamadou, Trento
      Mining common genetic variants impacting on allele-specific translation potential and cancer risk

      B.18 Laura Leo, Rome
      High-throughput drug screening uncovers compounds modulating ADAR epitranscriptomic enzymes and inhibiting glioblastoma cell proliferation and invasion

      B.19 Valeria Lucchino, Catanzaro
      The reduction of zinc finger ZZ-type containing 3 (ZZZ3) influences the proliferation of human embryonic stem cells (hESCs) by modulating the mTOR and ribosome biogenesis pathways

      B.20 Stefania Martucciello, Fisciano (SA)
      Tbx1 interacts with Vegfr3 to regulate cardiac morphogenesis

      B.21 Elisabetta Meacci, Florence
      Irisin regulation in skeletal muscle: a role for  sphingosine-1-phosphate -mediated signaling

      B.22 Giuseppe Neri, Pisa
      Navigating the rett syndrome genomic landscape with rettdb

      B.23 Elena Orecchini, Rome
      ADAR2-modified Extracellular vesicles (EV) against glioblastoma

      B.24 Giorgia Panebianco, Padua
      Maintenance of naive human pluripotent stem cells in feeder-free conditions

      B.25 Mattia Pelizzola, Milan
      Nanodynamo quantifies the dynamics of RNA metabolism and reveals extensive coupling between steps of the RNA life cycle

      B.26 Christian Ramirez, Trento
      METTL3 inhibition modulates RNA structure, A-to-I editing and immune response in leukemia models

      B.27 Valentina Salsi, Modena
      FRG2A is part of a novel family of lncRNAs affecting nucleolus-associated chromatin interactions and function in FSHD cells

      B.28 Jahnavi Srivatsa, Turin
      TFDP1 and E2F3 transcription factors identified as regulators of aggressiveness in basal-like breast cancer by gene co-expression network analysis

      B.29 Cecilia Torboli, Trento
      Gene and microRNA expression profiling of breast tumors from Chinese and Italian women

      B.30 Angela Valentino, Verona
      Generation of CRISPR/Cas9 miR-34a knock-out cell lines to identify novel miR-34a target genes

      B.31 Mauro Voi, Verona
      CRISPR/Cas9-mediated generation of HADHA KO PANC-1 cells to study the role of HADHA in pancreatic cancer stemness

      B.32 Clara Zannino, Catanzaro
      Ascorbic acid counteracts the oxidative stress effects in a human model of SCN1A-related febrile seizure and mesial temporal lobe epilepsy

    • Tuesday, 18 June, 16:10-17:40

      C.1 Ludovica Altieri, Rome
      The mitotic protein CENP-F localises to microtubule-based structures and is functionally repurposed during early neurogenic commitment and ciliogenesis

      C.2 Maria Balbontin Arenas, Segrate (MI)
      Neural Precursor Cells as a therapeutic approach for Rett syndrome: identification of the involved molecular mechanisms

      C.3 Davide Benvegnù, Padua
      Study of the metabolic changes during early mouse embryonic development

      C.4 Jacopo Biotti, Busto Arsizio
      UHRF1 acts as positive prognostic factor in gastric cancer repressing embryonic morphogenesis genes

      C.5 Ilaria Brentari, Trento
      Optimizing RNA therapies for dementia using hiPSC-derived FTDP-17 neuronal model

      C.6 Giulia Buonaiuto, Rome
      The nuclear lncRNA Charme plays an evolutionarily conserved role in the epigenetic regulation of muscle differentiation

      C.7 Davide Capuano, Bari
      Site-directed RNA editing for correcting point mutations causing fALS

      C.8 Ágata Carreira, Trento
      Targeting DiPeptide Repeats (DPRs) derived from G4C2 expansion of C9Orf72 gene in Amyotrophic Lateral Sclerosis (ALS)

      C.9 Chiara Cicconetti, Turin
      Unravelling the role of de novo DNA methylation in the transition from primed pluripotency to skeletal muscle fate

      C.10 Paolo Emidio Costantini, Bologna
      Molecular engineering of the M13 phage for potent signal amplification in electrochemiluminescent biosensing

      C.11 Samuele Crotti, Modena
      HSPB3 loss impairs motor neuron differentiation and the maturation of neuromuscular junctions

      C.12 Serena Di Savino, Trento
      In vivo inhibition of C1 improves dystrophic muscles’ phenotype observed in a mouse model of DMD

      C.13 Tania Fiaschi, Florence
      An autocrine loop of lactate sustains cachexia in skeletal muscle through GPR81 receptor

      C.14 Alessandro Framarini, Trieste
      Exploring OCT4 pathways mediated cancer aggressiveness in ovarian cancer

      C.15 Federico Galvagni, Siena
      NRF2 activation by cysteine as a survival mechanism for triple-negative breast cancer cells

      C.16 Marco Giovine, Genoa
      The involvement of miRNA in Aurelia aurita metamorphosis

      C.17 Nunzio Iraci, Catania
      Aging and neuroprotection: insights from astrocyte-derived extracellular vesicles in Parkinson's disease

      C.18 Domenico Liguoro, Rome
      Self-assembling nanoparticles for miRNA delivery towards precision medicine against melanoma

      C.19 Luca Marchetti, Povo (TN)
      A computational platform to support the development and optimization of mRNA-based vaccines and therapeutics

      C.20 Pietro Mazzacuva, Rome
      Profiling A to I RNA Editing via TCN-based Classifier

      C.21 Giulia Miglietta, Bologna
      Multi-omic analyses of G-Quadruplex-mediated micronuclei as a trigger of innate immune responses in cancer cells

      C.22 Francesco Nicassio, Milan
      Multi-omic lineage tracing predicts the transcriptional, epigenetic and genetic determinants of cancer evolution 

      C.23 Elisa Orlandi, Verona
      Axl and fra 1 oncoproteins regulation by non-coding RNAs in melanoma cell lines

      C.24 Marta Paoli, Trento
      Sensitive tumor detection, accurate quantification, and cancer subtype classification using low-pass whole methylome sequencing of plasma DNA

      C.25 Gerardo Pepe, Rome
      A meta-analysis approach to gene regulatory network inference identifies key regulators of cardiovascular diseases

      C.26 Giada Rossignoli, Padua
      Exploring pluripotency: does JAK/STAT contribute to the plasticity of human naive stem cells?

      C.27 Domenico Alessandro Silvestris, Bari
      Identification, characterization and prioritization of neoantigens for personalized cancer immunotherapy

      C.28 Annalaura Tamburrini, Turin
      Uncovering the pivotal role of lncRNAs in cortical neuron differentiation from human embryonic stem cells

      C.29 Gabriele Trentini, Trento
      Searching for new therapeutic opportunities in Lafora disease

      C.30 Angelo Sante Varvara, Bari
      Comparative evaluation of long and short read sequencing technologies for human trio genotyping

      C.31 Antonia Voli, Fisciano (SA)
      Helicobacter pylori chronic infection promotes epigenetic silencing of TFF1 via IFNγ